L-Glutamine .................................. 5,000 mg
NutraFlora®*FOS (Fructooligosaccharides) ....... 250 mg
Acacia Fiber (soluble dietary fiber) ........... 500 mg
N-Acetyl-D-Glucosamine ......................... 250 mg
Intestamine® Powder, supplied by Douglas Laboratories®,
is a unique and convenient dietary supplement formula for
gastrointestinal support. Intestamine provides significant
amounts of L-glutamine, an amino acid that is important in
maintaining normal structure and function of the
gastrointestinal tract; NutraFlora®FOS, which selectively
provides nourishment for beneficial intestinal bacteria;
acacia fiber, which is fermented into short chain fatty acids
for the lower intestine; and N-Acetyl-D-Glucosamine,
which is used as a structural component of intestinal
mucous secretions. Intestamine is a taste-neutral powder
that mixes easily with juices and other beverages.
Glutamine. The amino acid glutamine plays a key role in
the metabolism, structure, and function of the entire gastrointestinal
(GI) tract, and its extensive immune system.
Glutamine is perhaps the major energy source for intestinal
cells, and under conditions of physiological stress the GI
tract benefits greatly from extra dietary glutamine.
Glutamine is the most abundant amino acid found in blood,
and is a vehicle for nitrogen transport. Glutamineconsuming
tissues, such as the GI tract, the liver, and the
immune system, use glutamine for the synthesis of
nucleotides, proteins, and amino sugars. Glutamine carries
potentially toxic ammonia to the kidneys for excretion, and
participates in maintaining normal acid-base balance.
The human intestinal tract removes as much as 12-13% of
the circulating blood glutamine in addition to the glutamine
absorbed from dietary origin. Intestinal mucosal cells need
glutamine as a nitrogen donor for the biosynthesis of a
number of important compounds, including nucleotides
needed for cell division, amino sugars for building the
glycosaminoglycans of intestinal mucous, amino acids that
are crucial for protein synthesis as well as for an energy
During physiological stress, such as starvation, physical
trauma, surgery, or inflammatory bowel disease, the
intestinal tract uses very large amounts of glutamine and
very little glucose for energy. This often results in a fall of
blood glutamine, and skeletal muscle is broken down to
supply more glutamine.
The immune cells of mucosa, mesentary and liver depend
on glutamine as a key nitrogen donor and energy source.
During infections of intestinal origin, immune cells need
more glutamine, and the liver's glutamine consumption can
rise about ten-fold. Intestinal infections, trauma or surgery
can result in lower blood glutamine levels and muscle
In summary, many clinical studies support the fact that
dietary glutamine is crucial in maintaining normal function
of the entire gastrointestinal tract, including the liver and
pancreas. Glutamine helps maintain normal intestinal
permeability, mucosal cell regeneration, and structure. At
the same time, glutamine supports normal immune
function of the gastrointestinal tract and the liver.
Most people who are concerned about their GI health will
benefit significantly from about 5 to 20 grams of
supplemental L-glutamine per day. Intestamine provides 5
grams of pure L-glutamine per serving.
NutraFlora®FOS. Each serving of Intestamine provides
250 mg of NutraFlora® brand of fructooligosaccharides
(FOS), a class of natural carbohydrates. FOS are nondiges-
tible, short-chain fructose oligomers that are utilized
almost exclusively by the beneficial bacteria in the
NutraFlora®FOS is a carbohydrate that passes through the
small intestine into the colon without being digested or
absorbed. Once in the colon, FOS selectively feeds the
beneficial symbiotic bacteria, such as Lactobacillus
acidophilus, Bifidobacteria, and other acid-producing
bacteria. Regular consumption of FOS has been shown to
support healthy levels of these beneficial bacteria in the
colon. This in turn creates a slightly acidic environment in
the colon that is inhospitable to potentially harmful bacteria
and other microorganisms, such as E. coli and Clostridium
Acacia Fiber. Intestamine supplies 500 mg of soluble,
fermentable dietary fiber from acacia fiber. Like FOS,
acacia fiber is not digested in the upper intestine, but
extensively fermented by the beneficial colonic microflora.
The fermentation products are short chain fatty acids, such
as acetic, propionic and butyric acid.
These short chain fatty acids have several functions in the
healthy colon. First, they provide an acid environment that
favors the growth of the acid-loving beneficial Lactobacilli
and Bifidobacteria. Second, short chain fatty acids are
important for colonic water absorption and a normal stool
consistency. And third, they are utilized as an energy
source by the cells of the colonic mucosa. Adequate
amounts of fermentable dietary fiber appear to be necessary
to maintain normal structure and function of the colonic
N-Acetyl-D-Glucosamine. Intestinal mucosal cells
produce large amounts of mucous that are constantly
secreted into the intestinal lumen. This mucous protects the
mucosal cells, and helps propel digested food throughout
the GI tract. Just like glucosamine (sold separately by
Douglas Laboratories as Glucosamine Sulfate), N-Acetyl-
D-Glucosamine (NAG) is a naturally occurring amino
sugar. NAG is found in glycosaminoglycans which are
major structural components in intestinal mucous
secretions as well as connective tissues.
Supplementation with these amino sugars often helps
maintain normal glycosaminoglycan synthesis and
intestinal mucous production. Healthy individuals can
easily convert glucosamine into NAG. However, in
patients with inflammatory intestinal diseases, this
conversion appears to be less effective. That's why for the
GI tract, NAG supplementation is usually preferred over
Intestamine provides 250 mg of NAG per serving to
support normal mucous production for intestinal health.
Intestamine may be a useful dietary supplement for those
who wish to provide dietary support for a healthy GI tract.
Intestamine can be taken regularly, and can be combined
with probiotic dietary supplements, such as Douglas
Laboratories' Bio-dophilus™ or similar products
delivering beneficial living bacteria.
Serving Size 1 Scoop (approx 6g) - Servings per Container 60
Each scoop provides:
* NutraFlora is a registered trademark of Golden Technologies Company, Inc.
Intestamine can be taken on a regular basis to maintain
proper GI function. For this purpose, one to two servings a
day are usually appropriate. This level will provide 5 to 10
grams of L-glutamine. Individuals with GI and catabolic
diseases should consult a health care professional for
appropriate use of Intestamine for their nutritional support.
Intestamine is unflavored and contains no additives. It
disperses easily in juices and other beverages with little
impact on taste. For best results, take with cold or roomtemperature
foods or liquids. Do not take with foods or
liquids that are hot or highly acidic.
No adverse effects have been reported.