Mag-Malate by Douglas Labs
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Mag-MalateMagnesium (amino acid chelate)*...............100 mg
Malic acid ...................................400 mg
Magnesium Amino Acid Chelate & Malic Acid
Mag-Malate tablets, provide magnesium and malic acid,
two key nutrients involved in energy production.
Mag-Malate provides magnesium as an Albion
glycine/lysine amino acid chelate, which has superior
absorption and is highly tolerated.
Adenosine triphosphate (ATP) is the body's primary
form of energy currency. The hydrolysis of ATP to
adenosine diphosphate (ADP) and phosphate is the
predominant reaction used to create energy for
physiological processes. Thus, generation of ATP is
the central goal of energy production
There are numerous routes of ATP production.
Three primary methods for generating ATP in skeletal
muscle include immediate, high intensity ATP
production, nonoxidative energy production, and
oxidative energy production.
Immediate, high intensity ATP production can be achieved through two primary reactions: the combination of ADP and
inorganic phosphate and the donation of a phosphate
from creatine phosphate to ADP. Both of these
systems are used for quick, intense energy production
in the muscles.
Nonoxidative energy production, or glycolysis, occurs in the anaerobic cytosol.
Oxidative energy production, a collective term often used to
describe the Kreb's cycle and the electron transport
system (ETS), occurs in the aerobic environment of
Energy production within the body is a complicated
process, involving numerous enzymes, cofactors, and
substrates. Among those substances crucial to ATP
generation are magnesium and malic acid.
Magnesium is a trace mineral that is
essential for energy metabolism. It is required as a
cofactor of enzymes in all three modes of ATP
production in the muscle. In immediate, high
intensity energy production, magnesium serves as an
essential enzyme cofactor in both the conversion of
ADP and inorganic phosphate to ATP and for the
conversion of ADP and creatine phosphate to ATP
and creatine. During glycolysis, magnesium is
required for many reactions, including that which
allows pyruvate to be transformed into Acetyl
Coenzyme A, the step that bridges anaerobic and
aerobic energy production. This step is especially
important as it allows the opportunity to derive
maximum energy by accessing the Kreb's cycle and
ETS. These final stages of energy production are the
most productive in terms of ATP generation. Once
again, magnesium is an essential cofactor in
numerous enzymes that catalyze the reactions that
drive these energy production systems, especially the
Malic acid, in the form of malate, is an
important component of the Kreb's cycle. In aerobic
conditions, malate is converted to oxaloacetate,
generating the fourth of four reducing agents produced
by the Kreb's cycle. Once generated, these reducing
agents are used in the ETS to generate ATP. Malate
is also an integral component of the malate-aspartate
shuttle, which shuttles reducing equivalents produced
in the cytosol into the mitochondria for use in energy
Although there are many steps in the Kreb's cycle,
studies have shown that of all the Kreb's cycle
intermediates, only malic acid seems prone to
depletion upon extreme physical exertion.
Supplemental malic acid has been shown in research
studies to increase the amount of malate in
mitochondria, and thus increase the energy production
capacity of the cell.
Despite their crucial role in energy production, many
people do not obtain sufficient amounts of
magnesium or malic acid from their diet.
Rich sources of magnesium include dark leafy greens,
whole grains, nuts, and legumes. Malic acid occurs
naturally in certain fruits, such as apples and apricots.
Depleted levels of either of these nutrients can have a
negative impact on energy production capabilities.
Therefore, supplementation with highly bioavailable
forms of magnesium and malic acid may have
beneficial effects on energy production capacity.
Each tablet contains:
*U.S. Patent Number 4,599,152 Albion Laboratories.
Two tablets daily as a dietary supplement or as
directed by your Health Care Professional.
Each bottle contains 90 Tablets